Odette Annable was born in Los Angeles, California. Her mother, Lydia, is Cuban. Her father, Victor Yustman, who is of Italian and French descent, was born in Bogotá, Colombia and raised in Nicaragua.
Odette Annable graduated from Woodcrest Christian High School in Riverside, California. After graduating, she had planned on getting a degree in business finance at Loyola Marymount University before she decided to pursue a career in acting.
Annable made her acting debut at an early age, playing a young, Spanish-speaking student named Rosa in Kindergarten Cop, and later moved on to various television shows and movies such as South Beach and October Road.
In 2007, she starred in the Lifetime original movie Reckless Behavior: Caught on Tape and followed it quickly with a lead role in J. J. Abrams’ Cloverfield. In addition to this, she made a short appearance in Walk Hard. She also provided the voice of the character Amata in Fallout 3. On January 29, 2008, Variety announced that she would appear in The Unborn, which was released in 2009.